29 septembre 2012

Beta2-Microglobulin Interpretation

Interpretation depends on the specific clinical indication and context. Low serum levels of beta2 microglobulin essentially indicate decreased disease activity in conditions for which beta2 microglobulin is used as a prognostic marker (multiple myeloma, lymphoma, leukemia) or the absence of such a disease process. However, low beta2 microglobulin levels are never used to rule out a particular disease (eg, lymphoma) in the absence of other more definitive tests. Increased serum beta2 microglobulin levels reflect increased activity of... [Lire la suite]
Posté par tnfalpha à 13:37 - Commentaires [0] - Permalien [#]

26 septembre 2012

Reference Range of beta2 microglobulin

Serum and plasma beta2 microglobulin values have emerged as markers for the activation of the cellular immune system, as well as a tumor marker in certain hematologic malignancies. Urine beta2 microglobulin values indicate renal filtration disorders. Measurement of values in both serum and urine can help distinguish a problem of cellular activation from a renal disorder. The reference range of beta2 microglobulin in urine samples is 0-0.3 µg/mL. In serum or plasma samples, the reference range is 0-3 µg/mL. It is recommended that... [Lire la suite]
Posté par tnfalpha à 14:54 - Commentaires [0] - Permalien [#]
24 septembre 2012

Clinical significance of Beta-2 microglobulin

In patients on long-term hemodialysis, it can aggregate into amyloid fibers that deposit in joint spaces, a disease known as dialysis-related amyloidosis.Mice models deficient for the β2 microglobulin gene have been engineered. These mice demonstrate that β2 microglobulin is necessary for cell surface expression of MHC class I and stability of the peptide binding groove. In fact, in the absence of β2 microglobulin, very limited amounts of MHC class I (classical and non-classical) molecules can be detected on the surface. In the... [Lire la suite]
Posté par tnfalpha à 09:00 - Commentaires [0] - Permalien [#]
18 septembre 2012

Structure and function of Beta-2 microglobulin

β2 microglobulin lies lateral to the α3 chain on the cell surface. Unlike α3, β2 has no transmembrane region. Directly above β2 (i.e. away from the cell) lies the α1 chain, which itself is lateral to the α2.β2 microglobulin associates not only with the alpha chain of MHC class I molecules, but also with class I-like molecules such as CD1 and Qa.An additional function is association with the HFE protein, together regulating the expression of hepcidin in the liver which targets the iron transporter ferroportin on the cytoplasmic... [Lire la suite]
Posté par tnfalpha à 16:08 - Commentaires [0] - Permalien [#]
13 septembre 2012

beta2 microglobulin

β2 microglobulin lies lateral to the α3 chain on the cell surface. Unlike α3, β2 has no transmembrane region. Directly above β2 (i.e. away from the cell) lies the α1 chain, which itself is lateral to the α2.β2 microglobulin associates not only with the alpha chain of MHC class I molecules, but also with class I-like molecules such as CD1 and Qa.An additional function is association with the HFE protein, together regulating the expression of hepcidin in the liver which targets the iron transporter ferroportin on the cytoplasmic... [Lire la suite]
Posté par tnfalpha à 14:25 - Commentaires [0] - Permalien [#]