Beta2 microglobulin can be determined in urine, serum, or plasma samples.

It is not necessary to draw the sample in a fasting state, and no special preparations are necessary.

Blood is collected by venipuncture in a red-top tube and centrifuged to separate serum from cells after clot formation.

Samples may be stored refrigerated at 2-8°C for 5 days. For longer storage (up to 6 months), samples should be stored frozen at -20°C. To avoid
repeated thawing and freezing, the samples should be aliquoted.

Bilirubin and hemolysis do not significantly affect the procedure. However, gross lipemia can interfere with results.

Beta2 microglobulin is a component of certain panels, such as chronic lymphocytic leukemia (CLL), lymphoma, or multiple myeloma
prognostic/monitoring panels.