12 octobre 2012

CCR5-Δ32

CCR5-Δ32 is a deletion mutation of a gene that has a specific impact on the function of T cells.At least one copy of CCR5-Δ32 is found in about (5-14%) of people of Northern European and in those of Northern European descent. There also is a small minority (1%) with the same mutation amongst Southern Europeans or Balkan Peninsula. It has been hypothesized that this allele was favored by natural selection during the Black Death for Northern Europeans. Prostitution in areas such as Corinth in Ancient Greece could have also infected... [Lire la suite]
Posté par tnfalpha à 16:07 - Commentaires [0] - Permalien [#]

12 octobre 2012

HIV and CCR5

HIV most commonly uses CCR5 and/or CXCR4 as a co-receptor to enter its target cells. Several chemokine receptors can function as viral coreceptors, but CCR5 is likely the most physiologically important coreceptor during natural infection. The normal ligands for this receptor, RANTES, MIP-1β, and MIP-1α, are able to suppress HIV-1 infection in vitro. In individuals infected with HIV, CCR5-using viruses are the predominant species isolated during the early stages of viral infection, suggesting that these viruses may have a selective... [Lire la suite]
Posté par tnfalpha à 16:06 - Commentaires [0] - Permalien [#]
12 octobre 2012

Function of CCR5

The CCR5 protein belongs to the beta chemokine receptors family of integral membrane proteins. It is a G protein-coupled receptor which functions as a chemokine receptor in the CC chemokine group.The natural chemokine ligands that bind to this receptor are RANTES (a chemotactic cytokine protein also known as CCL5) and macrophage inflammatory protein (MIP) 1α and 1β (also known as CCL3 and CCL4). It also interacts with CCL3L1.CCR5 is predominantly expressed on T cells, macrophages, dendritic cells and microglia. It is likely that CCR5... [Lire la suite]
Posté par tnfalpha à 16:03 - Commentaires [0] - Permalien [#]