14 octobre 2012

Knockout phenotype of Desmin

When the gene for desmin is knocked out it is no longer able to function properly. Mice with the desmin knockout gene develop normally and are fertile, however soon after birth they begin to show defects in skeletal, smooth and cardiac muscle; in particular the diaphragm and heart are affected. The mice without desmin are weaker and fatigue more easily than wild type mice and the muscle fibers are more likely to be damaged during contraction, presumably because the desmin is responsible for keeping the muscle fibers aligned. Mice... [Lire la suite]
Posté par tnfalpha à 11:00 - Commentaires [0] - Permalien [#]

14 octobre 2012

Putative functions of Desmin

The function of desmin has been deduced through studies in knockout mice, but the underlying mechanism of its action is not known. These possibilities may be the result of interactions with other proteins and not desmin itself. More research needs to be done on desmin's expression and interactions in the muscle cell in order to determine its exact function.Desmin is one of the earliest protein markers for muscle tissue in embryogenesis as it is detected in the somites of myoblasts. Although it is present early in the development of... [Lire la suite]
Posté par tnfalpha à 10:59 - Commentaires [0] - Permalien [#]
14 octobre 2012


Desmin is a protein that in humans is encoded by the DES gene.Desmin is a type III intermediate filament found near the Z line in sarcomeres. It was first described in 1976, first purified in 1977, the gene was cloned in 1989, and the first knock-out mouse was created in 1996. Desmin is only expressed in vertebrates, however homologous proteins are found in many organisms. It is a 52kD protein that is a subunit of intermediate filaments in skeletal muscle tissue, smooth muscle tissue, and cardiac muscle tissue.
Posté par tnfalpha à 10:54 - Commentaires [0] - Permalien [#]