14 octobre 2012

Putative functions of Desmin

The function of desmin has been deduced through studies in knockout mice, but the underlying mechanism of its action is not known. These possibilities may be the result of interactions with other proteins and not desmin itself. More research needs to be done on desmin's expression and interactions in the muscle cell in order to determine its exact function.Desmin is one of the earliest protein markers for muscle tissue in embryogenesis as it is detected in the somites of myoblasts. Although it is present early in the development of... [Lire la suite]
Posté par tnfalpha à 10:59 - Commentaires [0] - Permalien [#]

14 octobre 2012


Desmin is a protein that in humans is encoded by the DES gene.Desmin is a type III intermediate filament found near the Z line in sarcomeres. It was first described in 1976, first purified in 1977, the gene was cloned in 1989, and the first knock-out mouse was created in 1996. Desmin is only expressed in vertebrates, however homologous proteins are found in many organisms. It is a 52kD protein that is a subunit of intermediate filaments in skeletal muscle tissue, smooth muscle tissue, and cardiac muscle tissue.
Posté par tnfalpha à 10:54 - Commentaires [0] - Permalien [#]
12 octobre 2012


CCR5-Δ32 is a deletion mutation of a gene that has a specific impact on the function of T cells.At least one copy of CCR5-Δ32 is found in about (5-14%) of people of Northern European and in those of Northern European descent. There also is a small minority (1%) with the same mutation amongst Southern Europeans or Balkan Peninsula. It has been hypothesized that this allele was favored by natural selection during the Black Death for Northern Europeans. Prostitution in areas such as Corinth in Ancient Greece could have also infected... [Lire la suite]
Posté par tnfalpha à 16:07 - Commentaires [0] - Permalien [#]
12 octobre 2012

HIV and CCR5

HIV most commonly uses CCR5 and/or CXCR4 as a co-receptor to enter its target cells. Several chemokine receptors can function as viral coreceptors, but CCR5 is likely the most physiologically important coreceptor during natural infection. The normal ligands for this receptor, RANTES, MIP-1β, and MIP-1α, are able to suppress HIV-1 infection in vitro. In individuals infected with HIV, CCR5-using viruses are the predominant species isolated during the early stages of viral infection, suggesting that these viruses may have a selective... [Lire la suite]
Posté par tnfalpha à 16:06 - Commentaires [0] - Permalien [#]
12 octobre 2012

Function of CCR5

The CCR5 protein belongs to the beta chemokine receptors family of integral membrane proteins. It is a G protein-coupled receptor which functions as a chemokine receptor in the CC chemokine group.The natural chemokine ligands that bind to this receptor are RANTES (a chemotactic cytokine protein also known as CCL5) and macrophage inflammatory protein (MIP) 1α and 1β (also known as CCL3 and CCL4). It also interacts with CCL3L1.CCR5 is predominantly expressed on T cells, macrophages, dendritic cells and microglia. It is likely that CCR5... [Lire la suite]
Posté par tnfalpha à 16:03 - Commentaires [0] - Permalien [#]
11 octobre 2012


C-C chemokine receptor type 5, also known as CCR5 or CD195, is a protein on the surface of white blood cells that is involved in the immune system as it acts as a receptor for chemokines. This is the process by which T cells are attracted to specific tissue and organ targets. Many forms of HIV, the virus that causes AIDS, initially use CCR5 to enter and infect host cells. A few individuals carry a mutation known as CCR5-Δ32 in the CCR5 gene, protecting them against these strains of HIV.In humans, the CCR5 gene that encodes the CCR5... [Lire la suite]
Posté par tnfalpha à 10:12 - Commentaires [0] - Permalien [#]
05 octobre 2012

Collection and Panels of Beta2-Microglobulin

Beta2 microglobulin can be determined in urine, serum, or plasma samples. It is not necessary to draw the sample in a fasting state, and no special preparations are necessary. Blood is collected by venipuncture in a red-top tube and centrifuged to separate serum from cells after clot formation. Samples may be stored refrigerated at 2-8°C for 5 days. For longer storage (up to 6 months), samples should be stored frozen at -20°C. To avoid repeated thawing and freezing, the samples should be aliquoted. Bilirubin and hemolysis do not... [Lire la suite]
Posté par tnfalpha à 08:31 - Commentaires [0] - Permalien [#]