Post-translational modification of CBP Protein

Methylation of the KIX domain by CARM1 blocks association with CBP. This results in the blockade of CREB signaling, and in activation of apoptotic response By similarity.
Phosphorylated upon DNA damage, probably by ATM or ATR. Phosphorylated by CHUK/IKKA at Ser-1382 and Ser-1386; these phosphorylations promote cell growth by switching the binding preference of CREBBP from TP53 to NF-kappa-B.