03 novembre 2012

Post-translational modification of CBP Protein

Methylation of the KIX domain by CARM1 blocks association with CBP. This results in the blockade of CREB signaling, and in activation of apoptotic response By similarity. Phosphorylated upon DNA damage, probably by ATM or ATR. Phosphorylated by CHUK/IKKA at Ser-1382 and Ser-1386; these phosphorylations promote cell growth by switching the binding preference of CREBBP from TP53 to NF-kappa-B.
Posté par tnfalpha à 16:01 - Commentaires [0] - Permalien [#]

03 novembre 2012

CBP Protein Research Areas

The CBP Protein product can be utilized in the following research areas, but not limited to:   Apoptosis/Autophagy, Cardiovascular Disease, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Metabolic Disorder, Neurobiology, NfkB Pathway, PKA/PKC Pathway.
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03 novembre 2012

Scientific Background of CBP Protein

CBP or CREB-binding protein is a nuclear transcriptional coactivator protein that binds specifically to the PKA-phosphorylated form of the CREB protein. Microinjection of an anti-CBP antiserum into fibroblasts leads to inhibition of transcription from a cAMP promoter. CBP can also cooperates with upstream activators, such as JUN. When JUN is phosphorylated at the transcriptionally stimulatory sites ser73 and ser63, it binds CBP with comparable affinity to CREB. Insulin signaling may directly regulate many cAMP signaling pathways at... [Lire la suite]
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