07 novembre 2012

Axokine and CNTF

Axokine is a modified version of human Ciliary neurotrophic factor with a 15 amino acid truncation of the C terminus and two amino acid substitutions, which is three to five times more potent than CNTF in in vitro and in vivo assays and has improved stability properties. Like CNTF it is a neurotrophic factor, and may stimulate nerve cells to survive. It was tested in the 1990s as a treatment for amyotrophic lateral sclerosis. It did not improve muscle control as much as expected, but trial participants did report a loss of appetite.
Posté par tnfalpha à 15:28 - Commentaires [0] - Permalien [#]

07 novembre 2012

Satiety effects of CNTF

In 2001, CNTF was reported that in a human study examining the usefulness of CNTF for treatment of motor neuron disease, CNTF produced an unexpected and substantial weight loss in the study subjects. Further investigation revealed that CNTF could reduce food intake without causing hunger or stress, making it a candidate for weight control in leptin resistant subjects, as CNTF is believed to operate like leptin, but by a non-leptin pathway.
Posté par tnfalpha à 15:26 - Commentaires [0] - Permalien [#]
07 novembre 2012

Ciliary neurotrophic factor

CNTF encoded by this gene is a polypeptide hormone and nerve growth factor whose actions have mainly been studied in the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations including astrocytes. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype... [Lire la suite]
Posté par tnfalpha à 15:24 - Commentaires [0] - Permalien [#]