16 novembre 2012

AKT Binding phospholipids

AKT2 possesses a protein domain known as a PH domain, or Pleckstrin Homology domain, named after Pleckstrin, the protein in which it was first discovered. This domain binds to phosphoinositides with high affinity. In the case of the PH domain of Akt, it binds either PIP3 (phosphatidylinositol (3,4,5)-trisphosphate, PtdIns(3,4,5)P3) or PIP2 (phosphatidylinositol (3,4)-bisphosphate, PtdIns(3,4)P2). This is useful for control of cellular signaling because the di-phosphorylated phosphoinositide PIP2 is only phosphorylated by the family of... [Lire la suite]
Posté par tnfalpha à 17:40 - Commentaires [0] - Permalien [#]

16 novembre 2012

AKT Family members

AKT21 is involved in cellular survival pathways, by inhibiting apoptotic processes. Akt1 is also able to induce protein synthesis pathways, and is therefore a key signaling protein in the cellular pathways that lead to skeletal muscle hypertrophy, and general tissue growth. Since it can block apoptosis, and thereby promote cell survival, Akt1 has been implicated as a major factor in many types of cancer. Akt (now also called Akt1) was originally identified as the oncogene in the transforming retrovirus, AKT8. Akt2 is an important... [Lire la suite]
Posté par tnfalpha à 17:40 - Commentaires [0] - Permalien [#]
16 novembre 2012

AKT

AKT2, also known as Protein Kinase B (PKB), is a serine/threonine-specific protein kinase that plays a key role in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription and cell migration. The name Akt does not refer to its function. The "Ak" in Akt was a temporary classification name for a mouse strain originally bred and maintained by Jacob Furth that developed spontaneous thymic lymphomas. The "t" stands for 'thymoma'; the letter was added when a transforming retrovirus was isolated... [Lire la suite]
Posté par tnfalpha à 17:39 - Commentaires [0] - Permalien [#]