A polymorphism of the beta1-adrenergic receptor is associated with low extraversion . CONCLUSIONS: The lack of difference between propranolol and betaxolol suggests that ADRB1 blockade is sufficient to improve neuroleptic-induced akathisia . Metoprolol, a selective beta 1-adrenoreceptor blocker, was administered to two patients with intermittent explosive disorder who had not done well with previous medications, including propranolol and carbamazepine . These data indicate that a disruption of beta 1-adrenoceptor-G protein coupling occurs in the temporal cortex of Alzheimer's disease patients . Repeated electroconvulsive shock prevents increased neocortical beta 1-adrenoceptor binding after DSP-4 treatment in rats.