20 novembre 2012

High impact information on ADRB1

These results unambiguously prove that T. cruzi is able to induce a functional autoimmune response against the cardiovascular human ADRB1 through a molecular mimicry mechanism. Molecular mimicry between the immunodominant ribosomal protein P0 of Trypanosoma cruzi and a functional epitope on the human beta 1-adrenergic receptor. Subcutaneous abdominal adipose tissue of healthy non-obese subjects was microdialyzed with equimolar concentrations of dobutamine (selective beta 1-adrenoceptor agonist), terbutaline (selective beta... [Lire la suite]
Posté par tnfalpha à 16:02 - Commentaires [0] - Permalien [#]

20 novembre 2012

Psychiatry related information on ADRB1

A polymorphism of the beta1-adrenergic receptor is associated with low extraversion . CONCLUSIONS: The lack of difference between propranolol and betaxolol suggests that ADRB1 blockade is sufficient to improve neuroleptic-induced akathisia . Metoprolol, a selective beta 1-adrenoreceptor blocker, was administered to two patients with intermittent explosive disorder who had not done well with previous medications, including propranolol and carbamazepine . These data indicate that a disruption of beta 1-adrenoceptor-G protein coupling... [Lire la suite]
Posté par tnfalpha à 16:01 - Commentaires [0] - Permalien [#]
20 novembre 2012

Disease relevance of ADRB1

This is the first study to investigate the relationship between the Gly389Arg ADRB1 variant and obesity . These data also suggest that blocking ADRB-mediated angiogenesis could have therapeutic implications for the management of ovarian cancer. METHODS AND RESULTS: Patients with essential hypertension and echocardiographically diagnosed LVH were included in a double-blind study to receive treatment with either the angiotensin II type 1 receptor (AT1-receptor) antagonist irbesartan (n = 41), or the beta-1 adrenergic receptor blocker... [Lire la suite]
Posté par tnfalpha à 16:01 - Commentaires [0] - Permalien [#]