21 novembre 2012
High impact information on Acvr2b
We further show that RA and ACVR2B mutation have synergistic effects on vertebral patterning. None of the left-right patterning abnormalities and organogenesis defects identified in mice carrying mutations in Nodal or in genes encoding ActRIIA and ActRIIB coreceptors, including heart malformations, pulmonary isomerism, right-sided gut, and spleen hypoplasia, were observed in mice lacking ALK7.
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