21 novembre 2012

Biological context of Acvr2b

Mouse ACVR2B gene generates four transcriptional isoforms (Acvr2b(1-4)) via alternative splicing of two sequence domains located at the juxtaposition of the transmembrane domain. To investigate whether these splicing domains are essential for signal transduction of the Acvr2b receptor in vivo, we have generated a strain of mutant mice (Acvr2b(4/4)) which produce only the Acvr2b(4) isoform, which lacks both splicing domains. In the absence of its subfamily receptor Acvr2a, however, the development of Acvr2b(4/4) mice was arrested at... [Lire la suite]
Posté par tnfalpha à 13:09 - Commentaires [0] - Permalien [#]

21 novembre 2012

High impact information on Acvr2b

We further show that RA and ACVR2B mutation have synergistic effects on vertebral patterning. None of the left-right patterning abnormalities and organogenesis defects identified in mice carrying mutations in Nodal or in genes encoding ActRIIA and ActRIIB coreceptors, including heart malformations, pulmonary isomerism, right-sided gut, and spleen hypoplasia, were observed in mice lacking ALK7.
Posté par tnfalpha à 13:09 - Commentaires [0] - Permalien [#]
21 novembre 2012

Disease relevance of Acvr2b

To test this hypothesis, we examined laterality defects in mice carrying mutations in both ACVR2B and inversus viscerum (iv) genes, because iv(-/-) mice display a spectrum of laterality defects, including situs inversus, right isomerism, and left isomerism. ActRIIB mRNA was also found in brain, spinal cord, and ganglion, but usually appeared earlier in development than the ActRII message. Retinoic acid induces activin receptor IIB mRNA in F9 embryonal carcinoma cells.
Posté par tnfalpha à 13:08 - Commentaires [0] - Permalien [#]