23 novembre 2012

High impact information on Apoc2

Overexpression of APOC2 causes hypertriglyceridemia in transgenic mice. In the present studies, initial attempts to demonstrate cAMP-dependent activation of triglyceride lipase using the 1,000 X g supernatant fraction (S1) of mouse heart homogenate were unsuccessful, presumably due to the masking effects of high levels of lipoprotein lipase activity even when assayed at pH 7.4 and in the absence of apolipoprotein C-II.
Posté par tnfalpha à 16:07 - Commentaires [0] - Permalien [#]

23 novembre 2012

Disease relevance of Apoc2

Furthermore, the decrease of LPL activity in the heart, along with the inhibitory effects of excess APOC2, may contribute to the hypertriglyceridemia observed in apoC-II transgenic mice. Finally, we demonstrate that apolipoprotein C-II in human atheroma co-localizes to regions positive for markers of amyloid and macrophage accumulation.
Posté par tnfalpha à 16:06 - Commentaires [0] - Permalien [#]
23 novembre 2012


Apolipoprotein C2 or Apolipoprotein C-II is a protein that in humans is encoded by the APOC2 gene. The protein encoded by this gene is secreted in plasma where it is a component of very low density lipoproteins and chylomicrons. This protein activates the enzyme lipoprotein lipase in capillaries, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by xanthomas, pancreatitis, and hepatosplenomegaly, but no increased risk for... [Lire la suite]
Posté par tnfalpha à 16:05 - Commentaires [0] - Permalien [#]