tnf alpha

22 novembre 2012

Psychiatry related information on batroxobin

Comparison of all control and probucol-treated monkeys demonstrated that intimal lesion areas in the thoracic aortas of the probucol-treated monkeys were reduced by 43% (P < 0.0001), but no significant difference in lesion area was found in the abdominal...

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22 novembre 2012

Disease relevance of batroxobin

Mycotic aneurysm of the external iliac artery. A triad of clinical signs facilitating early diagnosis. The soluble 165-amino acid isoform of VEGF was administered as a single intra-arterial bolus to the internal iliac artery of rabbits in which the ipsilateral...

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21 novembre 2012

Biological context of Acvr2b

Mouse ACVR2B gene generates four transcriptional isoforms (Acvr2b(1-4)) via alternative splicing of two sequence domains located at the juxtaposition of the transmembrane domain. To investigate whether these splicing domains are essential for signal transduction...

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21 novembre 2012

High impact information on Acvr2b

We further show that RA and ACVR2B mutation have synergistic effects on vertebral patterning. None of the left-right patterning abnormalities and organogenesis defects identified in mice carrying mutations in Nodal or in genes encoding ActRIIA and ActRIIB...

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21 novembre 2012

Disease relevance of Acvr2b

To test this hypothesis, we examined laterality defects in mice carrying mutations in both ACVR2B and inversus viscerum (iv) genes, because iv(-/-) mice display a spectrum of laterality defects, including situs inversus, right isomerism, and left isomerism....

Posté par tnfalpha à 13:08 - Commentaires […] - Permalien [#]

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20 novembre 2012

High impact information on ADRB1

These results unambiguously prove that T. cruzi is able to induce a functional autoimmune response against the cardiovascular human ADRB1 through a molecular mimicry mechanism. Molecular mimicry between the immunodominant ribosomal protein P0 of Trypanosoma...

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20 novembre 2012

Psychiatry related information on ADRB1

A polymorphism of the beta1-adrenergic receptor is associated with low extraversion . CONCLUSIONS: The lack of difference between propranolol and betaxolol suggests that ADRB1 blockade is sufficient to improve neuroleptic-induced akathisia . Metoprolol,...

Posté par tnfalpha à 16:01 - Commentaires […] - Permalien [#]

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20 novembre 2012

Disease relevance of ADRB1

This is the first study to investigate the relationship between the Gly389Arg ADRB1 variant and obesity . These data also suggest that blocking ADRB-mediated angiogenesis could have therapeutic implications for the management of ovarian cancer. METHODS...

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16 novembre 2012

AKT Binding phospholipids

AKT2 possesses a protein domain known as a PH domain, or Pleckstrin Homology domain, named after Pleckstrin, the protein in which it was first discovered. This domain binds to phosphoinositides with high affinity. In the case of the PH domain of Akt,...

Posté par tnfalpha à 17:40 - Commentaires […] - Permalien [#]

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16 novembre 2012

AKT Family members

AKT21 is involved in cellular survival pathways, by inhibiting apoptotic processes. Akt1 is also able to induce protein synthesis pathways, and is therefore a key signaling protein in the cellular pathways that lead to skeletal muscle hypertrophy, and...

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