02 décembre 2012

Inflammation with Annexin A1

Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins, and leukotrienes, Annexin A1 may have potential anti-inflammatory activity. Glucocorticoids stimulate production of lipocortin. In this way, synthesis of eicosanoids are inhibited.
Posté par tnfalpha à 13:31 - Commentaires [0] - Permalien [#]

02 décembre 2012

Function of Annexin A1

Annexin A1 belongs to the annexin family of Ca2+-dependent phospholipid-binding proteins that have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity.
Posté par tnfalpha à 13:31 - Commentaires [0] - Permalien [#]
02 décembre 2012

Annexin A1

Annexin A1 also known as lipocortin I is a protein that in humans is encoded by the ANXA1 gene. Annexin-A1 has also been shown to be protective against DNA damage induced by heat in breast cancer cells, adding to the evidence that it has tumor suppressive and protective activities. When ANXA1 is silenced or lost in cancer, cells are more prone to DNA damage, indicating its unidentified diverse role in genome maintenance or integrity.
Posté par tnfalpha à 13:30 - Commentaires [0] - Permalien [#]