18 décembre 2012

High impact information on Anxa1

Blocked negative selection of developing T cells in mice expressing the baculovirus p35 caspase inhibitor. We have purified two phospholipase A2 inhibitory proteins (Annexin A1) from peritoneal fluid of dexamethasone-treated rats. Dexamethasone induces the synthesis of a phospholipase A2-inhibitory protein (PLIP) of molecular weight approximately equal to 55,000 from calf thymus and PLIPs of molecular weights 55,000, 40,000, 28,000, and 15,000 from A/J mouse thymus and from 12-day embryonic B10.
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18 décembre 2012

Disease relevance of Anxa1

In the zymosan peritonitis model, AnxA1 null mice displayed a higher degree (50-70%) of PMN recruitment compared with wild-type littermate mice, and this was associated with reduced numbers of F4/80+ cells . Down-regulation of the anti-inflammatory protein Annexin A1 in cystic fibrosis knock-out mice and patients.
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18 décembre 2012

annexin A1 Mus musculus

tnfalpha.canalblog.com
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