24 décembre 2012

Associations of Bdnf with chemical compounds

Although proneurotrophins have been considered inactive precursors, we show here that the proforms of nerve growth factor (NGF) and the proforms of brain derived neurotrophic factor (BDNF) are secreted and cleaved extracellularly by the serine protease plasmin and by selective matrix metalloproteinases (MMPs). In contrast to BDNF, the action of NT4 was independent of calcium influx through NMDA receptors and L-type calcium channels.
Posté par tnfalpha à 02:31 - Commentaires [0] - Permalien [#]

24 décembre 2012

NGF and BDNF

BDNF, but not NGF, supports the survival of cultured retinal ganglion cells but both NGF and BDNF promote the survival of septal cholinergic neurons in vitro. Here we report the effects of BDNF on the survival of dopaminergic neurons of the developing substantia nigra.
Posté par tnfalpha à 02:30 - Commentaires [0] - Permalien [#]
24 décembre 2012

Anatomical context of Bdnf

BDNF was expressed in the myocytes of the viable border zone. Even at low concentrations, brain-derived neurotrophic factor (BDNF) excited neurons in the hippocampus, cortex and cerebellum. In adult rats, injection of NT-3 (but not BDNF) into the lesioned spinal cord increases the regenerative sprouting of the transected CST.
Posté par tnfalpha à 02:30 - Commentaires [0] - Permalien [#]