27 décembre 2012

High impact information on BAX

Moreover, BCL-XL, BCL-2, and BAX can form ion-conductive pores in artificial membranes [5]. The percentage of myocytes labeled with BCL2 (which protects cells against apoptosis) was 1.8 times as high in the hearts of patients with cardiac failure as in the normal hearts, whereas labeling with BAX (which promotes apoptosis) remained constant. Bax (Bcl2-associated X protein) is an apoptosis-inducing protein that participates in cell death during normal development and in various diseases.
Posté par tnfalpha à 02:31 - Commentaires [0] - Permalien [#]

27 décembre 2012

Elevated BAX

Surprisingly, we observed elevated BAX levels in patients with thyroid carcinomas compared with patients with adenomas (unpaired t-test: p<0.05) or with goitres (p<0.02). We conclude that BAX expression may represent a prognostic indicator for patients with ovarian cancer and that the combined evaluation of BAX and BCL-2 may provide additional prognostic significance.
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27 décembre 2012

Disease relevance of BAX

Loss of BAX also renders colorectal cancer cells resistant to TRAIL/Apo2L-mediated radiosensitization. These same v-BCL-2 proteins cooperate with loss of retinoblastoma protein and p53 tumor suppressor function, by inactivating the BAX and BAK apoptotic pathway to promote epithelial solid tumor growth and resistance to chemotherapy. This is in clear contrast to other carcinomas where BAX is frequently inactivated which correlates to a poor prognosis . There were no significant differences of the BAX levels between goitres or the... [Lire la suite]
Posté par tnfalpha à 02:31 - Commentaires [0] - Permalien [#]