21 décembre 2012

Physical interactions of BMPR1A

Using the structure of BMP-2 bound to its type I receptor (ALK3) as a guide, we introduced mutations in the context of the inhibin betaA cDNA and assessed the signaling activity of the resulting mutant BMPR1A.
Posté par tnfalpha à 01:08 - Commentaires [0] - Permalien [#]

21 décembre 2012

Associations of BMPR1A with chemical compounds

Mutations in SMAD4 and BMPR1A, implicated in the Transforming Growth Factor beta pathway, have recently been characterized, and hold significance in the management of patients and at risk family members .
Posté par tnfalpha à 01:07 - Commentaires [0] - Permalien [#]
21 décembre 2012

Anatomical context of BMPR1A

Using somatic cell hybrid and FISH analyses, the BMPR1A, BMPR1B, and BMPR2 genes were assigned to 10q23, 4q22-24, and 2q33-34, respectively. Severe pulmonary hypertension is associated with an increased expression of the angiogenic factor, angiopoietin-1, which shuts off the expression of BMPR1A, a transmembrane protein necessary for BMPR2 signalling, and thereby causes pulmonary artery smooth muscle cell proliferation.
Posté par tnfalpha à 01:06 - Commentaires [0] - Permalien [#]
20 décembre 2012

Anatomical context of Batroxobin

The right common carotid artery of the dog was perfused with Krebs-Henseleit solution at a constant pressure, 3,4-diaminopyridine (DAP), a selective potassium channel blocker was applied on the adventitia, and the luminal changes were observed with angiography and Batroxobin.
Posté par tnfalpha à 02:48 - Commentaires [0] - Permalien [#]
20 décembre 2012

High impact information on Batroxobin

In conclusion, intraoperative angioscopy provides visual assessment of luminal patency and anastomotic anatomy . Changes in coronary plaque color and morphology by lipid-lowering therapy with atorvastatin: serial evaluation by coronary Batroxobin.
Posté par tnfalpha à 02:48 - Commentaires [0] - Permalien [#]
20 décembre 2012

Batroxobin

Batroxobin is a serine protease derived from the venom of Bothrops atrox. Its molecular weight is approximately 43,000 g/mol−1. This thrombin-like proteolytic enzyme splits the 16 Arg-17 Gly bond in the A(alpha)-chain of fibrinogen, releasing fibrinopeptide A and leading to the clot formation through aggregation of formed of fibrin I monomer or Des-AA-monomer. In contrast to other anti-coagulants, it does not affect the functions of platelets. Hence, Batroxobin is used to determine fibrinogen in plasma, to measure a 'batroxobin... [Lire la suite]
Posté par tnfalpha à 02:47 - Commentaires [0] - Permalien [#]

18 décembre 2012

High impact information on Anxa1

Blocked negative selection of developing T cells in mice expressing the baculovirus p35 caspase inhibitor. We have purified two phospholipase A2 inhibitory proteins (Annexin A1) from peritoneal fluid of dexamethasone-treated rats. Dexamethasone induces the synthesis of a phospholipase A2-inhibitory protein (PLIP) of molecular weight approximately equal to 55,000 from calf thymus and PLIPs of molecular weights 55,000, 40,000, 28,000, and 15,000 from A/J mouse thymus and from 12-day embryonic B10.
Posté par tnfalpha à 14:44 - Commentaires [0] - Permalien [#]
18 décembre 2012

Disease relevance of Anxa1

In the zymosan peritonitis model, AnxA1 null mice displayed a higher degree (50-70%) of PMN recruitment compared with wild-type littermate mice, and this was associated with reduced numbers of F4/80+ cells . Down-regulation of the anti-inflammatory protein Annexin A1 in cystic fibrosis knock-out mice and patients.
Posté par tnfalpha à 14:44 - Commentaires [0] - Permalien [#]
18 décembre 2012

annexin A1 Mus musculus

tnfalpha.canalblog.com
Posté par tnfalpha à 14:44 - Commentaires [0] - Permalien [#]
02 décembre 2012

Inflammation with Annexin A1

Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins, and leukotrienes, Annexin A1 may have potential anti-inflammatory activity. Glucocorticoids stimulate production of lipocortin. In this way, synthesis of eicosanoids are inhibited.
Posté par tnfalpha à 13:31 - Commentaires [0] - Permalien [#]