01 janvier 2013

BCHE in UniProtKB/Swiss-Prot

Function: BCHE Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.
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01 janvier 2013

Entrez Gene summary for BCHE

Mutant alleles at the BCHE locus are responsible for suxamethonium sensitivity. Homozygous persons sustain prolonged apnea after administration of the muscle relaxant suxamethonium in connection with surgical anesthesia. The activity of pseudocholinesterase in the serum is low and its substrate behavior is atypical. In the absence of the relaxant, the homozygote is at no known disadvantage.
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01 janvier 2013

Drug interaction sites of BCHE

Overlapping drug interaction sites of human butyrylcholinesterase dissected by site-directed mutagenesis. Enzyme-linked immunosorbent assays for acetylcholinesterase (AChE) and for butyrylcholinesterase (BCHE) were markedly more specific than conventional assays using selective enzyme inhibitors. Butyrylcholinesterase in human brain and acetylcholinesterase in human plasma: trace enzymes measured by two-site immunoassay.
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