CDKN2A (gene) has been shown to interact with SERTAD1, CCNG1, Death associated protein 6, P53, E4F1, Cyclin-dependent kinase 4, Cyclin-dependent kinase 6, Mdm2, RPL11 and PPP1R9B. In spite of their structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in control of the G1 phase of the cell cycle. This gene is frequently mutated or deleted in a wide variety of tumors and is known to be an important tumor suppressor gene.