24 septembre 2012

Clinical significance of Beta-2 microglobulin

In patients on long-term hemodialysis, it can aggregate into amyloid fibers that deposit in joint spaces, a disease known as dialysis-related amyloidosis.Mice models deficient for the β2 microglobulin gene have been engineered. These mice demonstrate that β2 microglobulin is necessary for cell surface expression of MHC class I and stability of the peptide binding groove. In fact, in the absence of β2 microglobulin, very limited amounts of MHC class I (classical and non-classical) molecules can be detected on the surface. In the... [Lire la suite]
Posté par tnfalpha à 09:00 - Commentaires [0] - Permalien [#]

18 septembre 2012

Structure and function of Beta-2 microglobulin

β2 microglobulin lies lateral to the α3 chain on the cell surface. Unlike α3, β2 has no transmembrane region. Directly above β2 (i.e. away from the cell) lies the α1 chain, which itself is lateral to the α2.β2 microglobulin associates not only with the alpha chain of MHC class I molecules, but also with class I-like molecules such as CD1 and Qa.An additional function is association with the HFE protein, together regulating the expression of hepcidin in the liver which targets the iron transporter ferroportin on the cytoplasmic... [Lire la suite]
Posté par tnfalpha à 16:08 - Commentaires [0] - Permalien [#]
13 septembre 2012

beta2 microglobulin

β2 microglobulin lies lateral to the α3 chain on the cell surface. Unlike α3, β2 has no transmembrane region. Directly above β2 (i.e. away from the cell) lies the α1 chain, which itself is lateral to the α2.β2 microglobulin associates not only with the alpha chain of MHC class I molecules, but also with class I-like molecules such as CD1 and Qa.An additional function is association with the HFE protein, together regulating the expression of hepcidin in the liver which targets the iron transporter ferroportin on the cytoplasmic... [Lire la suite]
Posté par tnfalpha à 14:25 - Commentaires [0] - Permalien [#]
31 mai 2012

Receptor

Bevacizumab (Avastin ○ R) Bevacizumab (Avastin ○ R, rhuMAb-VEGF, Genetech Inc.) Receptor humanized antibody against vascular endothelial growth factor (VEGF), is currently the treatment of colorectal cancer and breast cancer stage Ⅲclinical studies. VEGF regulate angiogenesis, regulation of vascular permeability and function of anti-apoptotic effects on endothelial cells of neovascularization. Bevacizum ˉ ab monotherapy tumor has made a significant therapeutic effect, can also enhance anti-tumor efficacy of chemotherapy. In the... [Lire la suite]
Posté par tnfalpha à 16:42 - Commentaires [0] - Permalien [#]
12 mai 2012

TNF-alpha 001

TNF tumor cell plasma membrane with a certain period of the First performance ofspecific receptor binding at the cell surface to form a cap gathered into the roomcell, move along microtubules and lysosomes into the cell combined with TNF under the action of lysosomal rupture, releasinglysosomal enzymes resulting in cell autolysis. Clinical has been... [Lire la suite]
Posté par tnfalpha à 16:50 - Commentaires [0] - Permalien [#]