tnf alpha

27 décembre 2012

Disease relevance of BAX

Loss of BAX also renders colorectal cancer cells resistant to TRAIL/Apo2L-mediated radiosensitization. These same v-BCL-2 proteins cooperate with loss of retinoblastoma protein and p53 tumor suppressor function, by inactivating the BAX and BAK apoptotic...

Posté par tnfalpha à 02:31 - Commentaires […] - Permalien [#]

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26 décembre 2012

mRNA of BDNF

In situ hybridizations for BDNF and trkB mRNA revealed that virtually all CSNs express trkB, whereas only half of them express BDNF. As revealed with 5-HT immunocytochemistry, BDNF infusions into the neocortex of intact (non-PCA-lesioned) rats caused...

Posté par tnfalpha à 01:55 - Commentaires […] - Permalien [#]

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26 décembre 2012

Analytical, diagnostic and therapeutic context of Bdnf

The increase in BDNF mRNA was mediated by a selective activation of the BDNF exon IV promoter and adrenalectomy attenuated this increase by 50%. In bioassays, BDNF and NT-3, but not NGF, at physiological concentrations induced neurite outgrowth from the...

Posté par tnfalpha à 01:55 - Commentaires […] - Permalien [#]

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26 décembre 2012

Immunoreactivity of BDNF

The distribution of BDNF-induced neuropeptide Y immunoreactivity is similar to the pattern observed in animals submitted to hippocampal kindling, with the exception of mossy fibres which only become immunoreactive following seizure activity. We found...

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25 décembre 2012

BDNF in neuron

Although hippocampal neurons do not express typical LDCV proteins, transfected chromogranins A, B, and brain-derived neurotrophic factor (BDNF) colocalize with VMAT2.

Posté par tnfalpha à 02:09 - Commentaires […] - Permalien [#]

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25 décembre 2012

Expression of BDNF

These factors may act as the eventual repressors for BDNF expression via competition and heterodimerization with phosphorylated CREB, a transcription factor important for BDNF expression. Shp-2 specifically regulates several tyrosine-phosphorylated proteins...

Posté par tnfalpha à 02:08 - Commentaires […] - Permalien [#]

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25 décembre 2012

Enzymatic interactions of Bdnf

In contrast, multiple bolus microinjections of BDNF accelerated kindling development and did not affect the level of phosphorylated Trks or TrkB receptors. In contrast to shams, the acutely exercised FPI rats failed to show activity-dependent BDNF upregulation...

Posté par tnfalpha à 02:08 - Commentaires […] - Permalien [#]

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24 décembre 2012

Associations of Bdnf with chemical compounds

Although proneurotrophins have been considered inactive precursors, we show here that the proforms of nerve growth factor (NGF) and the proforms of brain derived neurotrophic factor (BDNF) are secreted and cleaved extracellularly by the serine protease...

Posté par tnfalpha à 02:31 - Commentaires […] - Permalien [#]

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24 décembre 2012

NGF and BDNF

BDNF, but not NGF, supports the survival of cultured retinal ganglion cells but both NGF and BDNF promote the survival of septal cholinergic neurons in vitro. Here we report the effects of BDNF on the survival of dopaminergic neurons of the developing...

Posté par tnfalpha à 02:30 - Commentaires […] - Permalien [#]

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24 décembre 2012

Anatomical context of Bdnf

BDNF was expressed in the myocytes of the viable border zone. Even at low concentrations, brain-derived neurotrophic factor (BDNF) excited neurons in the hippocampus, cortex and cerebellum. In adult rats, injection of NT-3 (but not BDNF) into the lesioned...

Posté par tnfalpha à 02:30 - Commentaires […] - Permalien [#]

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