23 décembre 2012

Paralle hypothesis of BDNF

In parallel studies, we observed a higher level of BDNF in EDL muscle during the critical period of development when motor neurons are highly susceptible to target removal. Dietary omega-3 fatty acids normalize BDNF levels, reduce oxidative damage, and counteract learning disability after traumatic brain injury in rats. The present study was conducted to test the hypothesis that BDNF in the hippocampus produces an antidepressant effect in behavioral models of depression, the learned helplessness (LH) and forced swim test (FST)... [Lire la suite]
Posté par tnfalpha à 02:30 - Commentaires [0] - Permalien [#]

23 décembre 2012

Psychiatry related information on Bdnf

Supranigral infusions of BDNF and NT-3 alter circadian rhythms, spontaneous motor activity, body weights, and amphetamine-induced behaviors including locomotion and contraversive rotations. Our findings show that neurotrophins are able to promote the survival of striatal projection neurons in vivo and suggest that BDNF might be beneficial for the treatment of striatonigral degenerative disorders, including Huntington's disease.
Posté par tnfalpha à 02:29 - Commentaires [0] - Permalien [#]
23 décembre 2012

Neurotrophic function of BDNF

BDNF and NT-3 decreased body weights, an effect that was sustained over the infusion period. Brain-derived neurotrophic factor activation of TrkB protects neuroblastoma cells from chemotherapy-induced apoptosis via phosphatidylinositol 3'-kinase pathway. Ischemia and reperfusion increased hippocampal levels of BDNF.
Posté par tnfalpha à 02:29 - Commentaires [0] - Permalien [#]
22 décembre 2012

Receptor of BDNF

The other BDNF receptor, the p75, plays a somewhat less clear role. Some researchers have shown that the p75NTR binds and serves as a "sink" for neurotrophins. Cells that express both the p75NTR and the Trk receptors might, therefore, have a greater activity, since they have a higher "microconcentration" of the neurotrophin. It has also been shown, however, that the p75NTR may signal a cell to die via apoptosis; so, therefore, cells expressing the p75NTR in the absence of Trk receptors may die rather than live in the presence of a... [Lire la suite]
Posté par tnfalpha à 03:29 - Commentaires [0] - Permalien [#]
22 décembre 2012

Secretion of BDNF

BDNF is made in the endoplasmic reticulum and secreted from dense-core vesicles. It binds carboxypeptidase E (CPE), and the disruption of this binding has been proposed to cause the loss of sorting of BDNF into dense-core vesicles. The phenotype for BDNF knockout mice can be severe, including postnatal lethality. Other traits include sensory neuron losses that affect coordination, balance, hearing, taste, and breathing. Knockout mice also exhibit cerebellar abnormalities and an increase in the number of sympathetic neurons. Exercise... [Lire la suite]
Posté par tnfalpha à 03:28 - Commentaires [0] - Permalien [#]
22 décembre 2012

Mechanism of action of BDNF

BDNF binds at least two receptors on the surface of cells that are capable of responding to this growth factor, TrkB (pronounced "Track B") and the LNGFR (for low-affinity nerve growth factor receptor, also known as p75). It may also modulate the activity of various neurotransmitter receptors, including the Alpha-7 nicotinic receptor. TrkB is a receptor tyrosine kinase (meaning it mediates its actions by causing the addition of phosphate molecules on certain tyrosines in the cell, activating cellular signaling). There are other... [Lire la suite]
Posté par tnfalpha à 03:28 - Commentaires [0] - Permalien [#]

21 décembre 2012

Physical interactions of BMPR1A

Using the structure of BMP-2 bound to its type I receptor (ALK3) as a guide, we introduced mutations in the context of the inhibin betaA cDNA and assessed the signaling activity of the resulting mutant BMPR1A.
Posté par tnfalpha à 01:08 - Commentaires [0] - Permalien [#]
21 décembre 2012

Associations of BMPR1A with chemical compounds

Mutations in SMAD4 and BMPR1A, implicated in the Transforming Growth Factor beta pathway, have recently been characterized, and hold significance in the management of patients and at risk family members .
Posté par tnfalpha à 01:07 - Commentaires [0] - Permalien [#]
21 décembre 2012

Anatomical context of BMPR1A

Using somatic cell hybrid and FISH analyses, the BMPR1A, BMPR1B, and BMPR2 genes were assigned to 10q23, 4q22-24, and 2q33-34, respectively. Severe pulmonary hypertension is associated with an increased expression of the angiogenic factor, angiopoietin-1, which shuts off the expression of BMPR1A, a transmembrane protein necessary for BMPR2 signalling, and thereby causes pulmonary artery smooth muscle cell proliferation.
Posté par tnfalpha à 01:06 - Commentaires [0] - Permalien [#]
20 décembre 2012

Anatomical context of Batroxobin

The right common carotid artery of the dog was perfused with Krebs-Henseleit solution at a constant pressure, 3,4-diaminopyridine (DAP), a selective potassium channel blocker was applied on the adventitia, and the luminal changes were observed with angiography and Batroxobin.
Posté par tnfalpha à 02:48 - Commentaires [0] - Permalien [#]