01 décembre 2012

Betacellulin

Betacellulin is a protein that in humans is encoded by the BTC gene located on chromosome 4 at locus 4q13-q21. Betacellulin is a member of the EGF family of growth factors. It is synthesized primarily as a transmembrane precursor, which is then processed to mature molecule by proteolytic events. This protein is a ligand for the EGF receptor.
Posté par tnfalpha à 15:26 - Commentaires [0] - Permalien [#]

29 novembre 2012

Interactions about BMPR1A

BMP's repress WNT signaling to maintain stable stem cell populations. BMPR1A null mice died at embyonic day 8.0 without mesoderm specification, demonstrating its vital role in gastrulation. It has been demonstrated in experiments using dominant negative BMPR1A chick embryos that BMPR1A plays a role in apoptosis and adipocyte development. Using constitutively active forms of BMR1A it has been shown that it plays a role in cell differentiation. Signals tranduced by the BMPR1A receptor are not essential for osteoblast formation or... [Lire la suite]
Posté par tnfalpha à 16:41 - Commentaires [0] - Permalien [#]
29 novembre 2012

Function of BMPR1A

The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A (this protein) and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about... [Lire la suite]
Posté par tnfalpha à 16:41 - Commentaires [0] - Permalien [#]
29 novembre 2012

BMPR1A

The bone morphogenetic protein receptor, type IA also known as BMPR1A is a protein which in humans is encoded by the BMPR1A gene. BMPR1A has also been designated as CD292. BMPR1A, SMAD4 and PTEN are responsible for Juvenile polyposis syndrome, juvenile intestinal polyposis and Cowden's disease.
Posté par tnfalpha à 16:40 - Commentaires [0] - Permalien [#]
26 novembre 2012

Chemical compound and disease context of BHMT

To initiate X-ray crystallographic structural studies, we created a BHMT expression construct for use in Escherichia coli that has a polyhistidine purification tag with no extraneous protein, usually found in commercial vectors, between the tag and protein sequence. Elevated levels of plasma homocysteine may be a risk factor for the development of vascular disease; however, whether BHMT has a significant role in the regulation of plasma levels of homocysteine remains to be determined.
Posté par tnfalpha à 16:18 - Commentaires [0] - Permalien [#]
26 novembre 2012

High impact information on BHMT

CBS and BHMT mRNA levels and the hepatic level of S-adenosylmethionine were also increased in the ZDF fa/fa rats. Furthermore, the severity of methionine restriction influenced the magnitude of BHMT induction. Concomitant with methionine restriction, dietary methyl groups were required for high levels of BHMT induction, and a dose-dependent relationship was observed between methyl donor intake and BHMT induction.
Posté par tnfalpha à 16:18 - Commentaires [0] - Permalien [#]

26 novembre 2012

Disease relevance of BHMT

A plasmid containing the human BHMT cDNA fused in frame to the N terminus of beta-galactosidase was transformed into Escherichia coli, and transformants expressed BHMT activity, an activity that is absent from wild type E. coli. Mutation analysis may reveal mutations of the BHMT gene that could lead to hyperhomocysteinemia.
Posté par tnfalpha à 16:18 - Commentaires [0] - Permalien [#]
23 novembre 2012

High impact information on Apoc2

Overexpression of APOC2 causes hypertriglyceridemia in transgenic mice. In the present studies, initial attempts to demonstrate cAMP-dependent activation of triglyceride lipase using the 1,000 X g supernatant fraction (S1) of mouse heart homogenate were unsuccessful, presumably due to the masking effects of high levels of lipoprotein lipase activity even when assayed at pH 7.4 and in the absence of apolipoprotein C-II.
Posté par tnfalpha à 16:07 - Commentaires [0] - Permalien [#]
23 novembre 2012

Disease relevance of Apoc2

Furthermore, the decrease of LPL activity in the heart, along with the inhibitory effects of excess APOC2, may contribute to the hypertriglyceridemia observed in apoC-II transgenic mice. Finally, we demonstrate that apolipoprotein C-II in human atheroma co-localizes to regions positive for markers of amyloid and macrophage accumulation.
Posté par tnfalpha à 16:06 - Commentaires [0] - Permalien [#]
23 novembre 2012

APOC2

Apolipoprotein C2 or Apolipoprotein C-II is a protein that in humans is encoded by the APOC2 gene. The protein encoded by this gene is secreted in plasma where it is a component of very low density lipoproteins and chylomicrons. This protein activates the enzyme lipoprotein lipase in capillaries, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by xanthomas, pancreatitis, and hepatosplenomegaly, but no increased risk for... [Lire la suite]
Posté par tnfalpha à 16:05 - Commentaires [0] - Permalien [#]