22 novembre 2012

Chemical compound and disease context of batroxobin

Five lambs ( approximately 6 mo of age and 30 kg), with an external iliac artery and vein catheterized and fed to maintain body weight, were used to examine effects of close arterial infusion of batroxobin and branched-chain amino acids (BCAA) on net phenylalanine (Phe) uptake across the hind limb.
Posté par tnfalpha à 15:57 - Commentaires [0] - Permalien [#]

22 novembre 2012

Psychiatry related information on batroxobin

Comparison of all control and probucol-treated monkeys demonstrated that intimal lesion areas in the thoracic aortas of the probucol-treated monkeys were reduced by 43% (P < 0.0001), but no significant difference in lesion area was found in the abdominal batroxobin or in the iliac arteries.
Posté par tnfalpha à 15:56 - Commentaires [0] - Permalien [#]
22 novembre 2012

Disease relevance of batroxobin

Mycotic aneurysm of the external iliac artery. A triad of clinical signs facilitating early diagnosis. The soluble 165-amino acid isoform of VEGF was administered as a single intra-arterial bolus to the internal iliac artery of rabbits in which the ipsilateral femoral artery was excised to induce severe, unilateral hind limb ischemia. Heparin (30 U/kg), an antithrombin agent (argatroban, 0.05 mg/kg body weight) or a defibrinogenating drug (batroxobin, 0.05 U/kg) was locally infused into one side of the canine iliac artery after injury... [Lire la suite]
Posté par tnfalpha à 15:56 - Commentaires [0] - Permalien [#]
21 novembre 2012

Biological context of Acvr2b

Mouse ACVR2B gene generates four transcriptional isoforms (Acvr2b(1-4)) via alternative splicing of two sequence domains located at the juxtaposition of the transmembrane domain. To investigate whether these splicing domains are essential for signal transduction of the Acvr2b receptor in vivo, we have generated a strain of mutant mice (Acvr2b(4/4)) which produce only the Acvr2b(4) isoform, which lacks both splicing domains. In the absence of its subfamily receptor Acvr2a, however, the development of Acvr2b(4/4) mice was arrested at... [Lire la suite]
Posté par tnfalpha à 13:09 - Commentaires [0] - Permalien [#]
21 novembre 2012

High impact information on Acvr2b

We further show that RA and ACVR2B mutation have synergistic effects on vertebral patterning. None of the left-right patterning abnormalities and organogenesis defects identified in mice carrying mutations in Nodal or in genes encoding ActRIIA and ActRIIB coreceptors, including heart malformations, pulmonary isomerism, right-sided gut, and spleen hypoplasia, were observed in mice lacking ALK7.
Posté par tnfalpha à 13:09 - Commentaires [0] - Permalien [#]
21 novembre 2012

Disease relevance of Acvr2b

To test this hypothesis, we examined laterality defects in mice carrying mutations in both ACVR2B and inversus viscerum (iv) genes, because iv(-/-) mice display a spectrum of laterality defects, including situs inversus, right isomerism, and left isomerism. ActRIIB mRNA was also found in brain, spinal cord, and ganglion, but usually appeared earlier in development than the ActRII message. Retinoic acid induces activin receptor IIB mRNA in F9 embryonal carcinoma cells.
Posté par tnfalpha à 13:08 - Commentaires [0] - Permalien [#]

20 novembre 2012

High impact information on ADRB1

These results unambiguously prove that T. cruzi is able to induce a functional autoimmune response against the cardiovascular human ADRB1 through a molecular mimicry mechanism. Molecular mimicry between the immunodominant ribosomal protein P0 of Trypanosoma cruzi and a functional epitope on the human beta 1-adrenergic receptor. Subcutaneous abdominal adipose tissue of healthy non-obese subjects was microdialyzed with equimolar concentrations of dobutamine (selective beta 1-adrenoceptor agonist), terbutaline (selective beta... [Lire la suite]
Posté par tnfalpha à 16:02 - Commentaires [0] - Permalien [#]
20 novembre 2012

Psychiatry related information on ADRB1

A polymorphism of the beta1-adrenergic receptor is associated with low extraversion . CONCLUSIONS: The lack of difference between propranolol and betaxolol suggests that ADRB1 blockade is sufficient to improve neuroleptic-induced akathisia . Metoprolol, a selective beta 1-adrenoreceptor blocker, was administered to two patients with intermittent explosive disorder who had not done well with previous medications, including propranolol and carbamazepine . These data indicate that a disruption of beta 1-adrenoceptor-G protein coupling... [Lire la suite]
Posté par tnfalpha à 16:01 - Commentaires [0] - Permalien [#]
20 novembre 2012

Disease relevance of ADRB1

This is the first study to investigate the relationship between the Gly389Arg ADRB1 variant and obesity . These data also suggest that blocking ADRB-mediated angiogenesis could have therapeutic implications for the management of ovarian cancer. METHODS AND RESULTS: Patients with essential hypertension and echocardiographically diagnosed LVH were included in a double-blind study to receive treatment with either the angiotensin II type 1 receptor (AT1-receptor) antagonist irbesartan (n = 41), or the beta-1 adrenergic receptor blocker... [Lire la suite]
Posté par tnfalpha à 16:01 - Commentaires [0] - Permalien [#]
16 novembre 2012

AKT Binding phospholipids

AKT2 possesses a protein domain known as a PH domain, or Pleckstrin Homology domain, named after Pleckstrin, the protein in which it was first discovered. This domain binds to phosphoinositides with high affinity. In the case of the PH domain of Akt, it binds either PIP3 (phosphatidylinositol (3,4,5)-trisphosphate, PtdIns(3,4,5)P3) or PIP2 (phosphatidylinositol (3,4)-bisphosphate, PtdIns(3,4)P2). This is useful for control of cellular signaling because the di-phosphorylated phosphoinositide PIP2 is only phosphorylated by the family of... [Lire la suite]
Posté par tnfalpha à 17:40 - Commentaires [0] - Permalien [#]