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2 janvier 2013

p16 family

Six CDKN2A families had pancreatic cancer . They also show that families with the CDKN2A 113insArg mutation have an increased risk not only of multiple melanomas and pancreatic carcinoma but also of breast cancer. We previously described CDKN2A exon 2...
Posté par tnfalpha à 02:26 - Commentaires […] - Permalien [#]

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2 janvier 2013

Disease relevance of CDKN2A

Although germline CDKN2A coding mutations cosegregate with melanoma in 25-60% of families predisposed to the disease, there remains a number of mutation-negative families that demonstrate linkage of inherited melanoma to 9p21 markers. High frequency of...
Posté par tnfalpha à 02:26 - Commentaires […] - Permalien [#]

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2 janvier 2013

Interactions about p16

CDKN2A (gene) has been shown to interact with SERTAD1, CCNG1, Death associated protein 6, P53, E4F1, Cyclin-dependent kinase 4, Cyclin-dependent kinase 6, Mdm2, RPL11 and PPP1R9B. In spite of their structural and functional differences, the CDK inhibitor...
Posté par tnfalpha à 02:25 - Commentaires […] - Permalien [#]

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1 janvier 2013

BCHE in UniProtKB/Swiss-Prot

Function: BCHE Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.
Posté par tnfalpha à 01:51 - Commentaires […] - Permalien [#]

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1 janvier 2013

Entrez Gene summary for BCHE

Mutant alleles at the BCHE locus are responsible for suxamethonium sensitivity. Homozygous persons sustain prolonged apnea after administration of the muscle relaxant suxamethonium in connection with surgical anesthesia. The activity of pseudocholinesterase...
Posté par tnfalpha à 01:51 - Commentaires […] - Permalien [#]

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1 janvier 2013

Drug interaction sites of BCHE

Overlapping drug interaction sites of human butyrylcholinesterase dissected by site-directed mutagenesis. Enzyme-linked immunosorbent assays for acetylcholinesterase (AChE) and for butyrylcholinesterase (BCHE) were markedly more specific than conventional...
Posté par tnfalpha à 01:50 - Commentaires […] - Permalien [#]

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