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11 octobre 2012

CCR5

C-C chemokine receptor type 5, also known as CCR5 or CD195, is a protein on the surface of white blood cells that is involved in the immune system as it acts as a receptor for chemokines. This is the process by which T cells are attracted to specific...

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12 octobre 2012

HIV and CCR5

HIV most commonly uses CCR5 and/or CXCR4 as a co-receptor to enter its target cells. Several chemokine receptors can function as viral coreceptors, but CCR5 is likely the most physiologically important coreceptor during natural infection. The normal ligands...

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14 octobre 2012

Putative functions of Desmin

The function of desmin has been deduced through studies in knockout mice, but the underlying mechanism of its action is not known. These possibilities may be the result of interactions with other proteins and not desmin itself. More research needs to...

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17 octobre 2012

CYP24A1

De1,25-dihydroxyvitamin D3 24-hydroxylase, mitochondrial is an enzyme that in humans is encoded by the CYP24A1 gene.This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze...

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17 octobre 2012

Function of CYP24A1

This mitochondrial protein initiates the degradation of 1,25-dihydroxyvitamin D3, the physiologically active form of vitamin D3, by hydroxylation of the side chain to form calcitroic acid.In regulating the level of vitamin D3, this enzyme plays a role...

Posté par tnfalpha à 14:57 - Commentaires […] - Permalien [#]

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24 décembre 2012

Associations of Bdnf with chemical compounds

Although proneurotrophins have been considered inactive precursors, we show here that the proforms of nerve growth factor (NGF) and the proforms of brain derived neurotrophic factor (BDNF) are secreted and cleaved extracellularly by the serine protease...

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12 mai 2012

TNF-alpha 001

TNF tumor cell plasma membrane with a certain period of the First performance ofspecific receptor binding at the cell surface to form a cap gathered into the roomcell, move along microtubules and lysosomes into the cell combined with TNF under the action...

Posté par tnfalpha à 16:50 - Commentaires […] - Permalien [#]

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7 novembre 2012

Axokine and CNTF

Axokine is a modified version of human Ciliary neurotrophic factor with a 15 amino acid truncation of the C terminus and two amino acid substitutions, which is three to five times more potent than CNTF in in vitro and in vivo assays and has improved stability...

Posté par tnfalpha à 15:28 - Commentaires […] - Permalien [#]

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24 décembre 2012

Anatomical context of Bdnf

BDNF was expressed in the myocytes of the viable border zone. Even at low concentrations, brain-derived neurotrophic factor (BDNF) excited neurons in the hippocampus, cortex and cerebellum. In adult rats, injection of NT-3 (but not BDNF) into the lesioned...

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26 décembre 2012

mRNA of BDNF

In situ hybridizations for BDNF and trkB mRNA revealed that virtually all CSNs express trkB, whereas only half of them express BDNF. As revealed with 5-HT immunocytochemistry, BDNF infusions into the neocortex of intact (non-PCA-lesioned) rats caused...

Posté par tnfalpha à 01:55 - Commentaires […] - Permalien [#]

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27 décembre 2012

Disease relevance of BAX

Loss of BAX also renders colorectal cancer cells resistant to TRAIL/Apo2L-mediated radiosensitization. These same v-BCL-2 proteins cooperate with loss of retinoblastoma protein and p53 tumor suppressor function, by inactivating the BAX and BAK apoptotic...

Posté par tnfalpha à 02:31 - Commentaires […] - Permalien [#]

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29 décembre 2012

Entrez Gene summary for BAX

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BAX forms a heterodimer with BCL2,...

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30 décembre 2012

Restriction analysis of BCHE

PvuII restriction analysis and DNA blot hybridization of the amplified ACHE and BCHE sequences demonstrated apparent aberrations in both genes, suggesting that malfunctioning of modified, partially amplified cholinesterase genes may be involved in the...

Posté par tnfalpha à 02:32 - Commentaires […] - Permalien [#]

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2 janvier 2013

p16 family

Six CDKN2A families had pancreatic cancer . They also show that families with the CDKN2A 113insArg mutation have an increased risk not only of multiple melanomas and pancreatic carcinoma but also of breast cancer. We previously described CDKN2A exon 2...

Posté par tnfalpha à 02:26 - Commentaires […] - Permalien [#]

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16 novembre 2012

AKT

AKT2, also known as Protein Kinase B (PKB), is a serine/threonine-specific protein kinase that plays a key role in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription and cell migration. The name Akt does...

Posté par tnfalpha à 17:39 - Commentaires […] - Permalien [#]

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27 décembre 2012

Elevated BAX

Surprisingly, we observed elevated BAX levels in patients with thyroid carcinomas compared with patients with adenomas (unpaired t-test: p<0.05) or with goitres (p<0.02). We conclude that BAX expression may represent a prognostic indicator for patients...

Posté par tnfalpha à 02:31 - Commentaires […] - Permalien [#]

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27 décembre 2012

High impact information on BAX

Moreover, BCL-XL, BCL-2, and BAX can form ion-conductive pores in artificial membranes [5]. The percentage of myocytes labeled with BCL2 (which protects cells against apoptosis) was 1.8 times as high in the hearts of patients with cardiac failure as in...

Posté par tnfalpha à 02:31 - Commentaires […] - Permalien [#]

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31 mai 2012

Receptor

Bevacizumab (Avastin ○ R) Bevacizumab (Avastin ○ R, rhuMAb-VEGF, Genetech Inc.) Receptor humanized antibody against vascular endothelial growth factor (VEGF), is currently the treatment of colorectal cancer and breast cancer stage Ⅲclinical studies. VEGF...

Posté par tnfalpha à 16:42 - Commentaires […] - Permalien [#]

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13 septembre 2012

beta2 microglobulin

β2 microglobulin lies lateral to the α3 chain on the cell surface. Unlike α3, β2 has no transmembrane region. Directly above β2 (i.e. away from the cell) lies the α1 chain, which itself is lateral to the α2.β2 microglobulin associates not only with the...

Posté par tnfalpha à 14:25 - Commentaires […] - Permalien [#]

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18 septembre 2012

Structure and function of Beta-2 microglobulin

β2 microglobulin lies lateral to the α3 chain on the cell surface. Unlike α3, β2 has no transmembrane region. Directly above β2 (i.e. away from the cell) lies the α1 chain, which itself is lateral to the α2.β2 microglobulin associates not only with the...

Posté par tnfalpha à 16:08 - Commentaires […] - Permalien [#]

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24 septembre 2012

Clinical significance of Beta-2 microglobulin

In patients on long-term hemodialysis, it can aggregate into amyloid fibers that deposit in joint spaces, a disease known as dialysis-related amyloidosis.Mice models deficient for the β2 microglobulin gene have been engineered. These mice demonstrate...

Posté par tnfalpha à 09:00 - Commentaires […] - Permalien [#]

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26 septembre 2012

Reference Range of beta2 microglobulin

Serum and plasma beta2 microglobulin values have emerged as markers for the activation of the cellular immune system, as well as a tumor marker in certain hematologic malignancies. Urine beta2 microglobulin values indicate renal filtration disorders....

Posté par tnfalpha à 14:54 - Commentaires […] - Permalien [#]

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29 septembre 2012

Beta2-Microglobulin Interpretation

Interpretation depends on the specific clinical indication and context. Low serum levels of beta2 microglobulin essentially indicate decreased disease activity in conditions for which beta2 microglobulin is used as a prognostic marker (multiple myeloma,...

Posté par tnfalpha à 13:37 - Commentaires […] - Permalien [#]

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5 octobre 2012

Collection and Panels of Beta2-Microglobulin

Beta2 microglobulin can be determined in urine, serum, or plasma samples. It is not necessary to draw the sample in a fasting state, and no special preparations are necessary. Blood is collected by venipuncture in a red-top tube and centrifuged to separate...

Posté par tnfalpha à 08:31 - Commentaires […] - Permalien [#]

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12 octobre 2012

Function of CCR5

The CCR5 protein belongs to the beta chemokine receptors family of integral membrane proteins. It is a G protein-coupled receptor which functions as a chemokine receptor in the CC chemokine group.The natural chemokine ligands that bind to this receptor...

Posté par tnfalpha à 16:03 - Commentaires […] - Permalien [#]

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