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18 décembre 2012

High impact information on Anxa1

Blocked negative selection of developing T cells in mice expressing the baculovirus p35 caspase inhibitor. We have purified two phospholipase A2 inhibitory proteins (Annexin A1) from peritoneal fluid of dexamethasone-treated rats. Dexamethasone induces...

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18 décembre 2012

Disease relevance of Anxa1

In the zymosan peritonitis model, AnxA1 null mice displayed a higher degree (50-70%) of PMN recruitment compared with wild-type littermate mice, and this was associated with reduced numbers of F4/80+ cells . Down-regulation of the anti-inflammatory protein...

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2 décembre 2012

Function of Annexin A1

Annexin A1 belongs to the annexin family of Ca2+-dependent phospholipid-binding proteins that have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has...

Posté par tnfalpha à 13:31 - Commentaires […] - Permalien [#]

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2 décembre 2012

Annexin A1

Annexin A1 also known as lipocortin I is a protein that in humans is encoded by the ANXA1 gene. Annexin-A1 has also been shown to be protective against DNA damage induced by heat in breast cancer cells, adding to the evidence that it has tumor suppressive...

Posté par tnfalpha à 13:30 - Commentaires […] - Permalien [#]

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1 décembre 2012

About the Image for Betacellulin

The structure for the small protein Betacellulin that is shown was determined by two-dimensional nuclear magnetic resonance spectroscopy. The species that BTC was taken from was Homo sapiens.This particular molecule of BTC has a formula weight of 5916.9...

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1 décembre 2012

Betacellulin

Betacellulin is a protein that in humans is encoded by the BTC gene located on chromosome 4 at locus 4q13-q21. Betacellulin is a member of the EGF family of growth factors. It is synthesized primarily as a transmembrane precursor, which is then processed...

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29 novembre 2012

Interactions about BMPR1A

BMP's repress WNT signaling to maintain stable stem cell populations. BMPR1A null mice died at embyonic day 8.0 without mesoderm specification, demonstrating its vital role in gastrulation. It has been demonstrated in experiments using dominant negative...

Posté par tnfalpha à 16:41 - Commentaires […] - Permalien [#]

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29 novembre 2012

Function of BMPR1A

The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A (this protein) and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin...

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1 décembre 2012

Structure of Betacellulin

Betacellulin was originally identified as a growth-promoting factor in mouse pancreatic β-cell carcinoma cell line and has since been identified in humans. Mouse BTC (mBTC) is expressed as a 178-amino acid precursor. The membrane-bound precursor is cleaved...

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26 novembre 2012

Chemical compound and disease context of BHMT

To initiate X-ray crystallographic structural studies, we created a BHMT expression construct for use in Escherichia coli that has a polyhistidine purification tag with no extraneous protein, usually found in commercial vectors, between the tag and protein...

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26 novembre 2012

High impact information on BHMT

CBS and BHMT mRNA levels and the hepatic level of S-adenosylmethionine were also increased in the ZDF fa/fa rats. Furthermore, the severity of methionine restriction influenced the magnitude of BHMT induction. Concomitant with methionine restriction,...

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26 novembre 2012

Disease relevance of BHMT

A plasmid containing the human BHMT cDNA fused in frame to the N terminus of beta-galactosidase was transformed into Escherichia coli, and transformants expressed BHMT activity, an activity that is absent from wild type E. coli. Mutation analysis may...

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23 novembre 2012

High impact information on Apoc2

Overexpression of APOC2 causes hypertriglyceridemia in transgenic mice. In the present studies, initial attempts to demonstrate cAMP-dependent activation of triglyceride lipase using the 1,000 X g supernatant fraction (S1) of mouse heart homogenate were...

Posté par tnfalpha à 16:07 - Commentaires […] - Permalien [#]

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23 novembre 2012

Disease relevance of Apoc2

Furthermore, the decrease of LPL activity in the heart, along with the inhibitory effects of excess APOC2, may contribute to the hypertriglyceridemia observed in apoC-II transgenic mice. Finally, we demonstrate that apolipoprotein C-II in human atheroma...

Posté par tnfalpha à 16:06 - Commentaires […] - Permalien [#]

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23 novembre 2012

APOC2

Apolipoprotein C2 or Apolipoprotein C-II is a protein that in humans is encoded by the APOC2 gene. The protein encoded by this gene is secreted in plasma where it is a component of very low density lipoproteins and chylomicrons. This protein activates...

Posté par tnfalpha à 16:05 - Commentaires […] - Permalien [#]

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22 novembre 2012

Disease relevance of batroxobin

Mycotic aneurysm of the external iliac artery. A triad of clinical signs facilitating early diagnosis. The soluble 165-amino acid isoform of VEGF was administered as a single intra-arterial bolus to the internal iliac artery of rabbits in which the ipsilateral...

Posté par tnfalpha à 15:56 - Commentaires […] - Permalien [#]

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21 novembre 2012

Biological context of Acvr2b

Mouse ACVR2B gene generates four transcriptional isoforms (Acvr2b(1-4)) via alternative splicing of two sequence domains located at the juxtaposition of the transmembrane domain. To investigate whether these splicing domains are essential for signal transduction...

Posté par tnfalpha à 13:09 - Commentaires […] - Permalien [#]

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21 novembre 2012

High impact information on Acvr2b

We further show that RA and ACVR2B mutation have synergistic effects on vertebral patterning. None of the left-right patterning abnormalities and organogenesis defects identified in mice carrying mutations in Nodal or in genes encoding ActRIIA and ActRIIB...

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21 novembre 2012

Disease relevance of Acvr2b

To test this hypothesis, we examined laterality defects in mice carrying mutations in both ACVR2B and inversus viscerum (iv) genes, because iv(-/-) mice display a spectrum of laterality defects, including situs inversus, right isomerism, and left isomerism....

Posté par tnfalpha à 13:08 - Commentaires […] - Permalien [#]

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20 novembre 2012

High impact information on ADRB1

These results unambiguously prove that T. cruzi is able to induce a functional autoimmune response against the cardiovascular human ADRB1 through a molecular mimicry mechanism. Molecular mimicry between the immunodominant ribosomal protein P0 of Trypanosoma...

Posté par tnfalpha à 16:02 - Commentaires […] - Permalien [#]

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20 novembre 2012

Psychiatry related information on ADRB1

A polymorphism of the beta1-adrenergic receptor is associated with low extraversion . CONCLUSIONS: The lack of difference between propranolol and betaxolol suggests that ADRB1 blockade is sufficient to improve neuroleptic-induced akathisia . Metoprolol,...

Posté par tnfalpha à 16:01 - Commentaires […] - Permalien [#]

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20 novembre 2012

Disease relevance of ADRB1

This is the first study to investigate the relationship between the Gly389Arg ADRB1 variant and obesity . These data also suggest that blocking ADRB-mediated angiogenesis could have therapeutic implications for the management of ovarian cancer. METHODS...

Posté par tnfalpha à 16:01 - Commentaires […] - Permalien [#]

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16 novembre 2012

AKT Binding phospholipids

AKT2 possesses a protein domain known as a PH domain, or Pleckstrin Homology domain, named after Pleckstrin, the protein in which it was first discovered. This domain binds to phosphoinositides with high affinity. In the case of the PH domain of Akt,...

Posté par tnfalpha à 17:40 - Commentaires […] - Permalien [#]

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7 novembre 2012

Satiety effects of CNTF

In 2001, CNTF was reported that in a human study examining the usefulness of CNTF for treatment of motor neuron disease, CNTF produced an unexpected and substantial weight loss in the study subjects. Further investigation revealed that CNTF could reduce...

Posté par tnfalpha à 15:26 - Commentaires […] - Permalien [#]

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16 novembre 2012

AKT Family members

AKT21 is involved in cellular survival pathways, by inhibiting apoptotic processes. Akt1 is also able to induce protein synthesis pathways, and is therefore a key signaling protein in the cellular pathways that lead to skeletal muscle hypertrophy, and...

Posté par tnfalpha à 17:40 - Commentaires […] - Permalien [#]

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