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7 novembre 2012

Ciliary neurotrophic factor

CNTF encoded by this gene is a polypeptide hormone and nerve growth factor whose actions have mainly been studied in the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations including astrocytes....

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6 novembre 2012

Entrez Gene summary for CEACAM1

CEACAM1 encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within...

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6 novembre 2012

CEACAM1

CEACAM1 encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within...

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3 novembre 2012

Post-translational modification of CBP Protein

Methylation of the KIX domain by CARM1 blocks association with CBP. This results in the blockade of CREB signaling, and in activation of apoptotic response By similarity. Phosphorylated upon DNA damage, probably by ATM or ATR. Phosphorylated by CHUK/IKKA...

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3 novembre 2012

Scientific Background of CBP Protein

CBP or CREB-binding protein is a nuclear transcriptional coactivator protein that binds specifically to the PKA-phosphorylated form of the CREB protein. Microinjection of an anti-CBP antiserum into fibroblasts leads to inhibition of transcription from...

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20 octobre 2012

Biological role of L-DOPA

L-tyrosine by the enzyme tyrosine hydroxylase (TH). It is also the precursor for the monoamine or catecholamine neurotransmitters dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline). Dopamine is formed by the decarboxylation of L-DOPA....

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20 octobre 2012

Therapeutic use of L-DOPA

L-DOPA crosses the protective blood–brain barrier, whereas dopamine itself cannot. Thus, L-DOPA is used to increase dopamine concentrations in the treatment of Parkinson's disease and dopamine-responsive dystonia. This treatment was originally developed...

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20 octobre 2012

L-DOPA

L-DOPA (L-3,4-dihydroxyphenylalanine) is a chemical that is made and used as part of the normal biology of some animals and plants. Some animals including humans make it via biosynthesis from the amino acid L-tyrosine. L-DOPA is the precursor to the neurotransmitters...

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19 octobre 2012

Metal binding of Metallothionein

Metallothionein has been documented to bind a wide range of metals including cadmium, zinc, mercury, copper, arsenic, silver, etc. Metallation of MT was previously reported to occur cooperatively but recent reports have provided strong evidence that metal-binding...

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19 octobre 2012

Structure and classification of Metallothionein

Metallothioneins are present in a vast range of taxonomic groups, ranging from prokaryotes (such as the cyanobacteria Syneccococus spp....), protozoa (p. ex. the ciliate Tetrahymena genera...), plants (such as Pisum sativum, Triticum durum, Zea mays,...

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17 octobre 2012

Entrez Gene summary for CYP24A1

CYP24A1 encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins aremonooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids andother lipids. This mitochondrial...

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14 octobre 2012

Knockout phenotype of Desmin

When the gene for desmin is knocked out it is no longer able to function properly. Mice with the desmin knockout gene develop normally and are fertile, however soon after birth they begin to show defects in skeletal, smooth and cardiac muscle; in particular...

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14 octobre 2012

Desmin

Desmin is a protein that in humans is encoded by the DES gene.Desmin is a type III intermediate filament found near the Z line in sarcomeres. It was first described in 1976, first purified in 1977, the gene was cloned in 1989, and the first knock-out...

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19 octobre 2012

Metallothionein

Metallothionein (MT) is a family of cysteine-rich, low molecular weight (MW ranging from 500 to 14000 Da) proteins. They are localized to the membrane of the Golgi apparatus. MTs have the capacity to bind both physiological (such as zinc, copper, selenium)...

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12 octobre 2012

CCR5-Δ32

CCR5-Δ32 is a deletion mutation of a gene that has a specific impact on the function of T cells.At least one copy of CCR5-Δ32 is found in about (5-14%) of people of Northern European and in those of Northern European descent. There also is a small minority...

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12 octobre 2012

Function of CCR5

The CCR5 protein belongs to the beta chemokine receptors family of integral membrane proteins. It is a G protein-coupled receptor which functions as a chemokine receptor in the CC chemokine group.The natural chemokine ligands that bind to this receptor...

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5 octobre 2012

Collection and Panels of Beta2-Microglobulin

Beta2 microglobulin can be determined in urine, serum, or plasma samples. It is not necessary to draw the sample in a fasting state, and no special preparations are necessary. Blood is collected by venipuncture in a red-top tube and centrifuged to separate...

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29 septembre 2012

Beta2-Microglobulin Interpretation

Interpretation depends on the specific clinical indication and context. Low serum levels of beta2 microglobulin essentially indicate decreased disease activity in conditions for which beta2 microglobulin is used as a prognostic marker (multiple myeloma,...

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26 septembre 2012

Reference Range of beta2 microglobulin

Serum and plasma beta2 microglobulin values have emerged as markers for the activation of the cellular immune system, as well as a tumor marker in certain hematologic malignancies. Urine beta2 microglobulin values indicate renal filtration disorders....

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24 septembre 2012

Clinical significance of Beta-2 microglobulin

In patients on long-term hemodialysis, it can aggregate into amyloid fibers that deposit in joint spaces, a disease known as dialysis-related amyloidosis.Mice models deficient for the β2 microglobulin gene have been engineered. These mice demonstrate...

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18 septembre 2012

Structure and function of Beta-2 microglobulin

β2 microglobulin lies lateral to the α3 chain on the cell surface. Unlike α3, β2 has no transmembrane region. Directly above β2 (i.e. away from the cell) lies the α1 chain, which itself is lateral to the α2.β2 microglobulin associates not only with the...

Posté par tnfalpha à 16:08 - Commentaires […] - Permalien [#]

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13 septembre 2012

beta2 microglobulin

β2 microglobulin lies lateral to the α3 chain on the cell surface. Unlike α3, β2 has no transmembrane region. Directly above β2 (i.e. away from the cell) lies the α1 chain, which itself is lateral to the α2.β2 microglobulin associates not only with the...

Posté par tnfalpha à 14:25 - Commentaires […] - Permalien [#]

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31 mai 2012

Receptor

Bevacizumab (Avastin ○ R) Bevacizumab (Avastin ○ R, rhuMAb-VEGF, Genetech Inc.) Receptor humanized antibody against vascular endothelial growth factor (VEGF), is currently the treatment of colorectal cancer and breast cancer stage Ⅲclinical studies. VEGF...

Posté par tnfalpha à 16:42 - Commentaires […] - Permalien [#]

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12 octobre 2012

HIV and CCR5

HIV most commonly uses CCR5 and/or CXCR4 as a co-receptor to enter its target cells. Several chemokine receptors can function as viral coreceptors, but CCR5 is likely the most physiologically important coreceptor during natural infection. The normal ligands...

Posté par tnfalpha à 16:06 - Commentaires […] - Permalien [#]

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11 octobre 2012

CCR5

C-C chemokine receptor type 5, also known as CCR5 or CD195, is a protein on the surface of white blood cells that is involved in the immune system as it acts as a receptor for chemokines. This is the process by which T cells are attracted to specific...

Posté par tnfalpha à 10:12 - Commentaires […] - Permalien [#]

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