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27 décembre 2012

High impact information on BAX

Moreover, BCL-XL, BCL-2, and BAX can form ion-conductive pores in artificial membranes [5]. The percentage of myocytes labeled with BCL2 (which protects cells against apoptosis) was 1.8 times as high in the hearts of patients with cardiac failure as in...

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27 décembre 2012

Elevated BAX

Surprisingly, we observed elevated BAX levels in patients with thyroid carcinomas compared with patients with adenomas (unpaired t-test: p<0.05) or with goitres (p<0.02). We conclude that BAX expression may represent a prognostic indicator for patients...

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16 novembre 2012

AKT

AKT2, also known as Protein Kinase B (PKB), is a serine/threonine-specific protein kinase that plays a key role in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription and cell migration. The name Akt does...

Posté par tnfalpha à 17:39 - Commentaires […] - Permalien [#]

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12 mai 2012

TNF-alpha 001

TNF tumor cell plasma membrane with a certain period of the First performance ofspecific receptor binding at the cell surface to form a cap gathered into the roomcell, move along microtubules and lysosomes into the cell combined with TNF under the action...

Posté par tnfalpha à 16:50 - Commentaires […] - Permalien [#]

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17 octobre 2012

Function of CYP24A1

This mitochondrial protein initiates the degradation of 1,25-dihydroxyvitamin D3, the physiologically active form of vitamin D3, by hydroxylation of the side chain to form calcitroic acid.In regulating the level of vitamin D3, this enzyme plays a role...

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17 octobre 2012

CYP24A1

De1,25-dihydroxyvitamin D3 24-hydroxylase, mitochondrial is an enzyme that in humans is encoded by the CYP24A1 gene.This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze...

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14 octobre 2012

Putative functions of Desmin

The function of desmin has been deduced through studies in knockout mice, but the underlying mechanism of its action is not known. These possibilities may be the result of interactions with other proteins and not desmin itself. More research needs to...

Posté par tnfalpha à 10:59 - Commentaires […] - Permalien [#]

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24 décembre 2012

Associations of Bdnf with chemical compounds

Although proneurotrophins have been considered inactive precursors, we show here that the proforms of nerve growth factor (NGF) and the proforms of brain derived neurotrophic factor (BDNF) are secreted and cleaved extracellularly by the serine protease...

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2 janvier 2013

p16 family

Six CDKN2A families had pancreatic cancer . They also show that families with the CDKN2A 113insArg mutation have an increased risk not only of multiple melanomas and pancreatic carcinoma but also of breast cancer. We previously described CDKN2A exon 2...

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30 décembre 2012

Restriction analysis of BCHE

PvuII restriction analysis and DNA blot hybridization of the amplified ACHE and BCHE sequences demonstrated apparent aberrations in both genes, suggesting that malfunctioning of modified, partially amplified cholinesterase genes may be involved in the...

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29 décembre 2012

Entrez Gene summary for BAX

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BAX forms a heterodimer with BCL2,...

Posté par tnfalpha à 01:30 - Commentaires […] - Permalien [#]

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27 décembre 2012

Disease relevance of BAX

Loss of BAX also renders colorectal cancer cells resistant to TRAIL/Apo2L-mediated radiosensitization. These same v-BCL-2 proteins cooperate with loss of retinoblastoma protein and p53 tumor suppressor function, by inactivating the BAX and BAK apoptotic...

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26 décembre 2012

mRNA of BDNF

In situ hybridizations for BDNF and trkB mRNA revealed that virtually all CSNs express trkB, whereas only half of them express BDNF. As revealed with 5-HT immunocytochemistry, BDNF infusions into the neocortex of intact (non-PCA-lesioned) rats caused...

Posté par tnfalpha à 01:55 - Commentaires […] - Permalien [#]

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24 décembre 2012

Anatomical context of Bdnf

BDNF was expressed in the myocytes of the viable border zone. Even at low concentrations, brain-derived neurotrophic factor (BDNF) excited neurons in the hippocampus, cortex and cerebellum. In adult rats, injection of NT-3 (but not BDNF) into the lesioned...

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7 novembre 2012

Axokine and CNTF

Axokine is a modified version of human Ciliary neurotrophic factor with a 15 amino acid truncation of the C terminus and two amino acid substitutions, which is three to five times more potent than CNTF in in vitro and in vivo assays and has improved stability...

Posté par tnfalpha à 15:28 - Commentaires […] - Permalien [#]

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1 janvier 2013

BCHE in UniProtKB/Swiss-Prot

Function: BCHE Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.

Posté par tnfalpha à 01:51 - Commentaires […] - Permalien [#]

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25 décembre 2012

BDNF in neuron

Although hippocampal neurons do not express typical LDCV proteins, transfected chromogranins A, B, and brain-derived neurotrophic factor (BDNF) colocalize with VMAT2.

Posté par tnfalpha à 02:09 - Commentaires […] - Permalien [#]

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21 décembre 2012

Physical interactions of BMPR1A

Using the structure of BMP-2 bound to its type I receptor (ALK3) as a guide, we introduced mutations in the context of the inhibin betaA cDNA and assessed the signaling activity of the resulting mutant BMPR1A.

Posté par tnfalpha à 01:08 - Commentaires […] - Permalien [#]

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21 décembre 2012

Associations of BMPR1A with chemical compounds

Mutations in SMAD4 and BMPR1A, implicated in the Transforming Growth Factor beta pathway, have recently been characterized, and hold significance in the management of patients and at risk family members .

Posté par tnfalpha à 01:07 - Commentaires […] - Permalien [#]

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20 décembre 2012

Anatomical context of Batroxobin

The right common carotid artery of the dog was perfused with Krebs-Henseleit solution at a constant pressure, 3,4-diaminopyridine (DAP), a selective potassium channel blocker was applied on the adventitia, and the luminal changes were observed with angiography...

Posté par tnfalpha à 02:48 - Commentaires […] - Permalien [#]

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20 décembre 2012

High impact information on Batroxobin

In conclusion, intraoperative angioscopy provides visual assessment of luminal patency and anastomotic anatomy . Changes in coronary plaque color and morphology by lipid-lowering therapy with atorvastatin: serial evaluation by coronary Batroxobin.

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18 décembre 2012

annexin A1 Mus musculus

tnfalpha.canalblog.com

Posté par tnfalpha à 14:44 - Commentaires […] - Permalien [#]

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2 décembre 2012

Inflammation with Annexin A1

Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins, and leukotrienes, Annexin A1 may have potential anti-inflammatory activity. Glucocorticoids stimulate production of lipocortin. In this way,...

Posté par tnfalpha à 13:31 - Commentaires […] - Permalien [#]

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29 novembre 2012

BMPR1A

The bone morphogenetic protein receptor, type IA also known as BMPR1A is a protein which in humans is encoded by the BMPR1A gene. BMPR1A has also been designated as CD292. BMPR1A, SMAD4 and PTEN are responsible for Juvenile polyposis syndrome, juvenile...

Posté par tnfalpha à 16:40 - Commentaires […] - Permalien [#]

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22 novembre 2012

Chemical compound and disease context of batroxobin

Five lambs ( approximately 6 mo of age and 30 kg), with an external iliac artery and vein catheterized and fed to maintain body weight, were used to examine effects of close arterial infusion of batroxobin and branched-chain amino acids (BCAA) on net...

Posté par tnfalpha à 15:57 - Commentaires […] - Permalien [#]

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