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2 janvier 2013

Disease relevance of CDKN2A

Although germline CDKN2A coding mutations cosegregate with melanoma in 25-60% of families predisposed to the disease, there remains a number of mutation-negative families that demonstrate linkage of inherited melanoma to 9p21 markers. High frequency of...

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2 janvier 2013

Interactions about p16

CDKN2A (gene) has been shown to interact with SERTAD1, CCNG1, Death associated protein 6, P53, E4F1, Cyclin-dependent kinase 4, Cyclin-dependent kinase 6, Mdm2, RPL11 and PPP1R9B. In spite of their structural and functional differences, the CDK inhibitor...

Posté par tnfalpha à 02:25 - Commentaires […] - Permalien [#]

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1 janvier 2013

Entrez Gene summary for BCHE

Mutant alleles at the BCHE locus are responsible for suxamethonium sensitivity. Homozygous persons sustain prolonged apnea after administration of the muscle relaxant suxamethonium in connection with surgical anesthesia. The activity of pseudocholinesterase...

Posté par tnfalpha à 01:51 - Commentaires […] - Permalien [#]

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1 janvier 2013

Drug interaction sites of BCHE

Overlapping drug interaction sites of human butyrylcholinesterase dissected by site-directed mutagenesis. Enzyme-linked immunosorbent assays for acetylcholinesterase (AChE) and for butyrylcholinesterase (BCHE) were markedly more specific than conventional...

Posté par tnfalpha à 01:50 - Commentaires […] - Permalien [#]

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31 décembre 2012

Extensiv incorporation of BCHE

BCHE variants (BCHE and CHE2 Loci) associated with erythrocyte acetylcholinesterase inhibition in farmers exposed to pesticides. The findings do not support the premise that inhibitor therapy should target BuChE so as to prevent increased levels of BuChE...

Posté par tnfalpha à 03:22 - Commentaires […] - Permalien [#]

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31 décembre 2012

Anatomical context of BCHE

Transient expression of BCHE-reporter gene constructs showed that a 194-bp fragment of the 5'-flanking region of human BCHE and a 570-bp fragment of rabbit BCHE were sufficient for promoting chloramphenicol acetyltransferase activity in HeLa cells. The...

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31 décembre 2012

BCHE and BuchE

An atypical form of butyrylcholinesterase or the absence of its activity leads to prolonged apnea following administration of the muscle relaxant suxamethonium. BCHE and obesity in individuals with the CHE2 C5+ and CHE2 C5- phenotypes. In this retrospective...

Posté par tnfalpha à 03:22 - Commentaires […] - Permalien [#]

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30 décembre 2012

Activity of BCHE

Protein concentration and acetylcholinesterase (AChE) and butyrylcholinesterase (BCHE) activities were assayed in the cerebrospinal fluid (CSF) of 26 healthy normal subjects (20-86 years old), 27 patients with dementia of the Alzheimer type (DAT), and...

Posté par tnfalpha à 02:32 - Commentaires […] - Permalien [#]

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30 décembre 2012

Psychiatry related information on BCHE

In Alzheimer's disease, BCHE may have thus acquired an inverse role to that of AChE by adopting imperfect amphipathic characteristics of its C terminus. Our results point to a possible association between an abnormal lipid metabolism and the BChE activity...

Posté par tnfalpha à 02:32 - Commentaires […] - Permalien [#]

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29 décembre 2012

BAX in immunoblotting

Significantly highernumbers of BAX positive hepatocytes were observed in HBsAg positive patients when compared to control groups. Immunoblotting revealed that BAX transfectants expressed a mean of 10-fold increased levels of BAX compared with neo-transfected...

Posté par tnfalpha à 01:29 - Commentaires […] - Permalien [#]

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29 décembre 2012

Analytical, diagnostic and therapeutic context of BAX

In 47 patients with thyroid tumours (14 follicular and 3 papillary carcinomas, 14 adenomas and 16 goitres), the DNA was screened for mutations of BAX (exon 1-6) and p53 (exon 5-8) by single-strand conformation polymorphism polymerase chain reaction (SSCP-PCR)....

Posté par tnfalpha à 01:29 - Commentaires […] - Permalien [#]

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28 décembre 2012

Cytotoxicity of BAX

The cytotoxicity of paclitaxel, vincristine, and doxorubicin was significantly enhanced in BAX transfectants compared with control clones, whereas the cytotoxicity profile of carboplatin, etoposide, and hydroxyurea was unchanged. The inhibitor benzyloxycarbonyl-Val-Ala-Asp-fluoromethyl...

Posté par tnfalpha à 03:06 - Commentaires […] - Permalien [#]

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28 décembre 2012

Associations of BAX with chemical compounds

Coexpression of BAD and NOXA killed wild-type but not Bax, Bak doubly deficient cells or Puma deficient cells with Bim knockdown, indicating that activator BH3-only molecules function downstream of inactivator BH3-only molecules to activate BAX-BAK. These...

Posté par tnfalpha à 03:06 - Commentaires […] - Permalien [#]

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28 décembre 2012

BAX treatment

Interestingly, LDFRT treatment in both cell lines with or without Paclitaxel down-regulated nuclear factor kappa B activity and BCL-2 protein expression and simultaneously up-regulated BAX protein. Recent genetic studies with fibroblasts derived from...

Posté par tnfalpha à 03:05 - Commentaires […] - Permalien [#]

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26 décembre 2012

Immunoreactivity of BDNF

The distribution of BDNF-induced neuropeptide Y immunoreactivity is similar to the pattern observed in animals submitted to hippocampal kindling, with the exception of mossy fibres which only become immunoreactive following seizure activity. We found...

Posté par tnfalpha à 01:55 - Commentaires […] - Permalien [#]

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25 décembre 2012

Expression of BDNF

These factors may act as the eventual repressors for BDNF expression via competition and heterodimerization with phosphorylated CREB, a transcription factor important for BDNF expression. Shp-2 specifically regulates several tyrosine-phosphorylated proteins...

Posté par tnfalpha à 02:08 - Commentaires […] - Permalien [#]

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25 décembre 2012

Enzymatic interactions of Bdnf

In contrast, multiple bolus microinjections of BDNF accelerated kindling development and did not affect the level of phosphorylated Trks or TrkB receptors. In contrast to shams, the acutely exercised FPI rats failed to show activity-dependent BDNF upregulation...

Posté par tnfalpha à 02:08 - Commentaires […] - Permalien [#]

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23 décembre 2012

Paralle hypothesis of BDNF

In parallel studies, we observed a higher level of BDNF in EDL muscle during the critical period of development when motor neurons are highly susceptible to target removal. Dietary omega-3 fatty acids normalize BDNF levels, reduce oxidative damage, and...

Posté par tnfalpha à 02:30 - Commentaires […] - Permalien [#]

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23 décembre 2012

Psychiatry related information on Bdnf

Supranigral infusions of BDNF and NT-3 alter circadian rhythms, spontaneous motor activity, body weights, and amphetamine-induced behaviors including locomotion and contraversive rotations. Our findings show that neurotrophins are able to promote the...

Posté par tnfalpha à 02:29 - Commentaires […] - Permalien [#]

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23 décembre 2012

Neurotrophic function of BDNF

BDNF and NT-3 decreased body weights, an effect that was sustained over the infusion period. Brain-derived neurotrophic factor activation of TrkB protects neuroblastoma cells from chemotherapy-induced apoptosis via phosphatidylinositol 3'-kinase pathway....

Posté par tnfalpha à 02:29 - Commentaires […] - Permalien [#]

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22 décembre 2012

Receptor of BDNF

The other BDNF receptor, the p75, plays a somewhat less clear role. Some researchers have shown that the p75NTR binds and serves as a "sink" for neurotrophins. Cells that express both the p75NTR and the Trk receptors might, therefore, have a greater activity,...

Posté par tnfalpha à 03:29 - Commentaires […] - Permalien [#]

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22 décembre 2012

Secretion of BDNF

BDNF is made in the endoplasmic reticulum and secreted from dense-core vesicles. It binds carboxypeptidase E (CPE), and the disruption of this binding has been proposed to cause the loss of sorting of BDNF into dense-core vesicles. The phenotype for BDNF...

Posté par tnfalpha à 03:28 - Commentaires […] - Permalien [#]

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22 décembre 2012

Mechanism of action of BDNF

BDNF binds at least two receptors on the surface of cells that are capable of responding to this growth factor, TrkB (pronounced "Track B") and the LNGFR (for low-affinity nerve growth factor receptor, also known as p75). It may also modulate the activity...

Posté par tnfalpha à 03:28 - Commentaires […] - Permalien [#]

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21 décembre 2012

Anatomical context of BMPR1A

Using somatic cell hybrid and FISH analyses, the BMPR1A, BMPR1B, and BMPR2 genes were assigned to 10q23, 4q22-24, and 2q33-34, respectively. Severe pulmonary hypertension is associated with an increased expression of the angiogenic factor, angiopoietin-1,...

Posté par tnfalpha à 01:06 - Commentaires […] - Permalien [#]

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20 décembre 2012

Batroxobin

Batroxobin is a serine protease derived from the venom of Bothrops atrox. Its molecular weight is approximately 43,000 g/mol−1. This thrombin-like proteolytic enzyme splits the 16 Arg-17 Gly bond in the A(alpha)-chain of fibrinogen, releasing fibrinopeptide...

Posté par tnfalpha à 02:47 - Commentaires […] - Permalien [#]

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